If you write spec fic, and you've been on the great agent hunt, there's fresh game afoot. The ever-useful Pikes Peak Writers list serve reported that there is a new agent out there and she handles science fiction (and YA, too, if you write that). The list serve cited a blog entry interviewing new agent Rachel Downes of the Caren Johnson Literary Agency. Caren Johnson represents fantasy authors, too, so the agency seems reasonably spec fic-friendly.
It looks like they only take e-queries; they even have their own online form.